| Pair Name | Codonopsis pilosula polysaccharide, Dacarbazine | ||
| Phytochemical Name | Codonopsis pilosula polysaccharide (PubChem CID: / ) | ||
| Anticancer drug Name | Dacarbazine (PubChem CID: 135398738 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Codonopsis pilosula polysaccharide, Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Gene Regulation | Up-regulation | Expression | IL1B | hsa3553 |
| Up-regulation | Expression | IL6 | hsa3569 | |
| Up-regulation | Expression | NOS2 | hsa4843 | |
| In Vitro Model | B16 | Mouse melanoma | Mus musculus (Mouse) | CVCL_F936 |
| In Vivo Model | To establish the tumor model, 1 × 106 B16 cells were suspended in 1 mL PBS buffer and 100 μL was injected subcutaneously into the right hind groin of each mouse. | |||
| Result | It could be deduced that GLCP, CPCP and dCPP hold great potential as safe therapeutic options for melanoma and an immune-modulator which may require further exploration. | |||
| No. | Title | Href |
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| 1 | Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages. Biomed Pharmacother. 2021;142:112016. doi:10.1016/j.biopha.2021.112016 | Click |
